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Dr Tim Pearce
Dr Agnes Shooshtarizadeh, MPharmS, PharmD, IP
Founder of Skin Boss Clinic
Dr Agnes Shooshtarizadeh is an independent pharmacist prescriber and master injector with special interest in longevity and holistic approach to aging and wellbeing through ( genetic )test based nutrition and bespoke supplements , holistic personalised aesthetic treatments, health optimisation and cancer prevention. She also passionate about latest research in genomics and formulation to improve targeted therapies. No guessing just science!
Biohacking is one of the most exciting and rapidly expanding scientific approaches to wellbeing, longevity, and healthy aging. It integrates cutting-edge science, lifestyle medicine, and personalised interventions to optimise health, slow biological aging, and prevent disease.
At Skin Boss Clinic, we approach aging holistically. By combining personalised supplementation with advanced cosmetic procedures and prescription skincare, we not only enhance aesthetic outcomes but also support systemic health. This integrative approach has been shown to improve energy levels, protect against chronic disease, and, in some cases, help manage chronic inflammatory conditions.
Today, advanced saliva-based genomic and epigenetic testing allows us to generate comprehensive reports—often exceeding 80 pages—providing insights into how individuals metabolise nutrients and vitamins, their telomere length, biological aging rate, and inflammatory tendencies. These results enable the creation of tailored supplementation and lifestyle plans designed to protect long-term health and promote longevity.
Why Do We Age?
Aging is a complex biological process influenced by genetic, environmental, and lifestyle factors. Several theories attempt to explain aging, with oxidative stress playing a central role.
The Free Radical Theory of Aging, also known as the oxidative stress theory, suggests that aging results from cumulative damage to cellular macromolecules—lipids, proteins, and DNA—caused by reactive oxygen and nitrogen species (RONS). These highly reactive molecules are produced through normal metabolic processes as well as external factors such as pollution, ultraviolet (UV) radiation, smoking, and poor diet.
Oxidative stress occurs when the production of RONS exceeds the body’s antioxidant defense capacity. This imbalance contributes to chronic inflammation, cellular dysfunction, and the progression of age-related diseases, including cardiovascular disease, neurodegenerative disorders, sarcopenia, and frailty.
Redox Regulation, Mitochondria, and Aging
Mitochondria play a critical role in aging through energy production and redox regulation. The concept of mitohormesis suggests that low levels of oxidative stress may stimulate adaptive cellular responses, improving resilience and longevity. However, excessive oxidative stress leads to mitochondrial dysfunction, impaired energy production, and accelerated aging.
Inflammation and Longevity
Inflammation is a vital physiological response that promotes tissue repair and immune defense. Acute inflammation is protective and self-limiting. In contrast, chronic low-grade inflammation—often referred to as “inflammaging”—contributes to tissue degeneration, immune dysfunction, and reduced lifespan.
Chronic inflammation is closely linked to oxidative stress, telomere shortening, and immune system decline. Supporting immune regulation and reducing inflammatory burden are therefore key strategies in healthy aging.
Skin Aging and Oxidative Stress
The skin, as the body’s largest organ, is continuously exposed to environmental stressors. UV radiation and pollution significantly increase reactive oxygen species production in the skin, leading to collagen degradation, elastin breakdown, DNA damage, and activation of matrix metalloproteinases. These processes contribute to photoaging, pigmentation disorders, inflammatory skin conditions, and increased skin cancer risk.
Maintaining a balance between oxidative stress and antioxidant defense is essential for preserving skin integrity and function.
Omega-3 Fatty Acids and Cellular Longevity
Higher omega-3 fatty acid levels are associated with longer telomeres, reduced inflammation, and improved stress resilience. Omega-3 fatty acids play a critical role in cell membrane structure, ensuring optimal fluidity and efficient nutrient transport.
At Skin Boss Clinic, we use Balance Oil, a high-quality omega-3 formulation infused with polyphenols. Polyphenols enhance antioxidant protection and maintain omega-3 bioavailability. Improving the omega-3 to omega-6 ratio has been shown to strengthen the skin barrier, reduce inflammation, and slow visible aging. Both topical and oral omega-3 supplementation support skin health and systemic wellbeing.
Clinical evidence supports the use of omega-3 fatty acids in dermatology, with benefits reported in psoriasis, atopic dermatitis, acne, skin ulcers, and photoprotection. Omega-3 supplementation is safe, cost-effective, and beneficial as an adjunctive therapy for inflammatory skin conditions.
Gut Health and the Immune System
Gut health plays a pivotal role in immunity, inflammation control, and nutrient absorption. The gut microbiome influences skin health, aging, and systemic inflammation. While probiotics introduce beneficial bacteria, prebiotics provide the essential fibre these bacteria need to thrive.
Achieving sufficient dietary fibre diversity is challenging, making targeted prebiotic supplementation beneficial for long-term health, inflammatory skin conditions, and acne management.
Phycocyanin: A Powerful Natural Antioxidant
Phycocyanin is a vibrant blue pigment derived from microalgae and cyanobacteria—some of the oldest photosynthetic organisms on Earth. These organisms evolved under extreme environmental stress and developed potent antioxidant defense systems.
Phycocyanin is widely researched for its anti-inflammatory, antioxidant, and anti-cancer adjuvant properties. Regular supplementation supports energy levels, protects against oxidative stress, and contributes to cellular longevity.
Conclusion
The future of aesthetics extends beyond isolated procedures. Comprehensive anti-aging lies in a sophisticated, holistic biohacking approach that integrates genomics, personalised supplementation, lifestyle optimisation, and tailored aesthetic treatments. By addressing aging at its biological root, we can enhance both longevity and quality of life.
References:
- Wang Y, Ma G. Natural antioxidants derived from microalgae and cyanobacteria and their applications in skincare. Blue Biotechnology. 2025;2:29. doi:10.1186/s44315-025-00050-w
- Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, et al. Oxidative stress, aging, and diseases. Clinical Interventions in Aging. 2018;13:757–772. doi:10.2147/CIA.S158513
- Russo GL, Spagnuolo C, Russo M, Tedesco I, Moccia S, Cervellera C. Mechanisms of aging and potential role of selected polyphenols in extending healthspan. Biochemical Pharmacology. 2019;173:113719. doi:10.1016/j.bcp.2019.113719
- Thomsen BJ, Chow EY, Sapijaszko MJ. The potential uses of omega-3 fatty acids in dermatology: a review. Journal of Cutaneous Medicine and Surgery. 2020;24(5):1–8. doi:10.1177/1203475420929925
Dr Tim Pearce eLearning
Dr Tim Pearce MBChB BSc (Hons) MRCGP founded his eLearning concept in 2016 in order to provide readily accessible BOTOX® and dermal filler online courses for fellow Medical Aesthetics practitioners. His objective was to raise standards within the industry – a principle which remains just as relevant today.
Our exclusive video-led courses are designed to build confidence, knowledge and technique at every stage, working from foundation level to advanced treatments and management of complications.
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